149 results
The intended research aims to evaluate whether a better suppression of adrenal androgens, so a better hormonal setting, can be achieved by changing the time of the highest dose in the morning or in the evening.
Primary hypothesis is whether patients with a PTSD the distraction of a positive emotional valence will be more effective in decreasing the vividness and emotionality of a traumatic memory compared to distraction with a neutral task or exposure only…
Since probenecid is a potent multi UGT inhibitor, endoxifen concentrations may be significantly (and clinically relevantly) increased when administered concomitantly with probenecid.
Flexible RPD's have a higher impact on OHRQoL compared to acrylic RPD's.
We hypothesize that especially the reward centres of the brain respond much stronger to processed food in BED, whereas much smaller differences are expected after consuming unprocessed food.
Home blood pressure measurement and 24 hour ambulatory blood pressure monitoring will be in good agreement with each other
• clonazepam administration has acute beneficial effects compared to placebo on neurocognitive tests. • multiple-doses clonazepam has beneficial effects compared to placebo on behaviour and cognitive function in ARID1B patients as measured by the…
In the first of two substudies, we test the hypothesis that in healthy individuals without ELS, hydrocortisone will be effective in enhancing stress adaptation and extinction learning in an experimental model of exposure therapy, while it is not in…
Golimumab 100 mg every 1,5 month has similar trough levels to golimumab 50 mg every month; golimumab 100 mg every 2 months has a similar AUC to golimumab 50 mg every month.
exercise improves social functioning, quality of life and decreases symptom severity
Adding specific components designed to target three risk factors for child maltreatment (parental stress, parental anger, and post-traumatic stress symptoms) to an evidence-based home visiting program alleviates these specific risk factors.
1. The addition of moderate positive end-expiratory pressure (PEEP, 7.5 cmH2O) to high inspiratory fractions of oxygen can either improve oxygenation or reduce respiratory rate, or both, in patients with severe Covid-19 pneumonia 2. The application…
2C-B generates distinct acute and subacute effects from Psilocybin and placebo
It is expected that differences in energy density of the study products will modulate the protein digestion profile of dairy proteins in elderly
Darolutamide (Nubeqa) is a novel androgen receptor antagonist drug for the treatment of non-metastatic castration resistant prostate cancer (CRPC), approved by the FDA and EMA. It does not inhibit major CYP enzymes or major transporters at…
In T2DM patients with DKD, an acute oral sodium load results in less renal sodium excretion than in healthy individuals and non-DKD T2DM, which can be restored by administration of a GLP-1 receptor agonist.
Cognitive remediation focused on executive functioning for patients with bipolar disorder improves executive functioning on (1) personal goals in daily life, and (2) general well-being. Exploratory hypotheses: - Cognitive remediation focused on…
Tamoxifen is metabolized in two steps, by CYP3A4 and CYP2D6, into endoxifen. Thereafter it is glucuronidated to its inactive excretable form through several UGT enzymes (UGT2B7, UGT1A4, UGT1A10 and UGT1A8) into endoxifen-glucuronide. CBD could also…
We hypothesize that added neurometabolite measurements can contribute to the interpretation of the ketamine phMRI response.
The hypothesis of this study is that implementation of an evidence-based management algorithm to standardize care will improve the level of care, lower the complication rate and improve the quality of life for patients with chronic pancreatitis.