182 results
The hypothesis of this study is that dosing everolimus 5mg twice daily(BID) instead of 10 mg once daily (QD) decreases the incidence of side effects, as a result of a lower Cmax while maintaining Cmin and AUC.
MCT is more effective than ERP, both statistically significant and clinically relevant.
We will investigate the effects of high dairy intake on metabolic flexibility, glucose metabolism and insulin sensitivity, which are all important characteristics of (metabolic) health. We hypothesize that high dairy intake improves insulin…
In this study we will investigate whether the effects of physical activity on cognitive performance are present after short (10 minutes), medium (20 minutes) or longer (30 minutes) bouts of moderate exercise in order to establish the feasibility of…
We hypothesize that there is no difference between the survival and follow of the uncemented and cemented ABG THA.
The immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae is different compared to pneumonia patients with another pathogen.
Objective: To assess the diuretic effect of three standard glasses of beer, red wine and spirits in euhydrated elderly men.
It is hypothesised that inhaled mannitol 400 mg b.d. will lead to a significant improvement in the absolute change in percentage of predicted FEV1 from baseline following eight-weeks of trial treatment compared to treatment with inhaled placebo b.d…
The Lokomat is an exo-skeleton that can be used to retrain gait skills in persons with post stroke hemiparesis. As of yet, it is still not clear what protocols should be used to obtain optimal treatment results in this population. In order to…
We hypothesize that formerly pre-eclamptic women have persistently increased angiotensin II sensitivity, sodium sensitivity, insulin resistance and sympathetic nerve activity together leading to susceptibility for early renal disease and…
Until recently, it was believed that the sodium (Na+) balance is only regulated by the kidney. Recent studies have revealed that the Na+ balance is not only regulated by the kidney, but also in the interstitium of the skin. Here, binding of Na+ to…
Part 1: Quantification of individual patient-prosthesis interactions - Determination of the instantaneous effect of prosthetic knees with variable biomechanical properties on the gait pattern of persons with an upper leg amputation (Part Ia). -…
2.2.1 Validation of existing demarcation formula In the present study, the existing demarcation formula will be validated. Its predictive power for Lybrido and Lybridos sensitivity will be measured using the subjects number of satisfying sexual…
Cytokine production differs when subjects ly on the rigid spineboard compared to the soft-layered spineboard.
For cochlear implanted (CI) patients speech recognition in noise still remains one of the most challenging tasks. One way to improve performance in noise is to benefit from binaural hearing (hearing with two ears). For individuals with residual…
Our hypothesis is that there is no difference in efficacy between perforation and perforation with application of one of the injection fluids. The potential health care efficiency gain consists of more homogeneity in the treatment of LE. Hereby,…
This research will have as aim to look at progression or decrease in vascular calcification in dialysis population with use different phosphate binders. There is a possibility that different binders bind vitamin K in a different way in intestinal…
With a daily activity programme concerning activities of daily life with occupational therapy by volunteers , physiotherapy and ergotherapy , probably functional decline does not develop or the condition of the patients can improve and it can reduce…
The primary objective of this study is to obtain clinical proof of principle that the Addition of a PgP/BCRP inhibitor increases CNS concentrations of tyrosine kinase inhibitors by inhibition of drug efflux transporter function in the blood brain…