177 results
Primary Objective: to ascertain whether administered clonidine and scopolamine affect performance (as measured by modulation of reaction times, learning and/or error rates) in a range of cognitive tasks designed to examine uncertainty estimation and…
(this text is taken from the protocol, see protocol for the detailed version)The main objective of the study is to gain insight in the underlying mechanism of tinnitus suppression. This objective will be achieved by comparing the suppressive effect…
This study is intended to establish a dose response rate of MR30507/09 with respect to respiratory effects compared to MR30365/07, fentanyl and placebo..
The major objective of the present study is to examine the effect of consuming vitamin E (804 mg) or lipoic acid (600 mg) for 4 weeks on fasting oxyphytosterol concentrations in subjects with impaired glucose tolerance or type 2 diabetes.
To find a simple test to explain non-responsiveness to sumatriptan in a proportion of patients with migraine.
In a fMRI experiment, will measure the changes in brain activity patterns and in functional connectivity. We hypothesize that a subanesthetic dose of S-Ketamine impairs the functional connectivity, especially the feedback connections that are…
Primary Objective: 1. Will an exposure to oxygen with a PO2 = 190 kPa lead to changes primarily in DLno compared to DLco?Secondary Objectives: 1. After an exposure to oxygen with a PO2 = 190 kPa for one hour, are the changes primarily located in the…
To compare the blood pressure lowering effect of thiazides against calcium channel blockers in CNI-induced hypertension.
Primary objective: To investigate whether pharmacokinetics of the recommended dose of inhaled tobramycin, defined as serum tobramycin Area Under the Curve (AUC0-24hr), with the I-neb (75 mg) is equivalent to the PariLCPlus (300 mg) nebuliser in…
Primary:Is the degree of pupildilation, achieved after administrating a 4.5 microliter microdrop tropicamide 0.5% equivalent to the pupildilation after a regular 30 microliter eydrop tropicamide 0.5% in healthy volunteers?Secondary: Is there a…
Main objective: to determine the effect, defined as the percentage of patients that show a clinical relevant improvement on the severity of complaints of nocturnal sialorrhea, of oral glycopyrroniumbromide in comparison with placebo in psychiatric…
The aim of the present study is to assess the contraceptive potential of the association of UPA 30 mg single dose and desogestrel 75 micrograms for 20 days. The study will also assess the potential possible interaction, (in terms of ovarian activity…
This study aims to investigate how serotonin influences social functioning in healthy adults with a first-degree family member diagnosed with MDD. The primary goal is to investigate the effect of an experimental increase in brain serotonin on…
To examine the effect of remote ischemic preconditioning on exercise-induced cTn elevations and indices of cardiac function.
The FLAVO-studie is a scientific study aimed at investgating if (and how) certain pure flavonoids can beneficially influence vascular function.
Primary objective:To show that addition of dead space to low-pressure nCPAP (which is usually not effective but can be relatively well tolerated) makes the therapy effective and diminishes the apnea hypopnea index with >10/hour in patients…
- To establish the pharmacokinetic profiles of saliva and plasma concentration of caffeine after a caffeinated beverage (two cups of espresso coffee) containing approximately 135 mg caffeine in total or one capsule containing 200 mg caffeine in…
The intended result is the discovery of an more effective, more simple, cheaper and more user-friendly treatment for positional OSA than current therapies. Positional therapies have been used as regular treatment in the Amsterdam Wake Sleep Center.…
To determine the potential pharmacokinetic interaction between GSE and dextromethorphan in healthy volunteers.
Primary: to assess the safety and tolerability of one oral dose of CB-189,625 at 6 dose levels in healthy male volunteers.Secondary: to determine the plasma pharmacokinetic profile of one oral dose of CB 189,625 at 6 dose levels in healthy…