72 results
The levels of performance decrement for the three blood alcohol concentrations will serve as a historical control for comparing the effects that will be observed with psychoactive drugs in future trials. This will make the results of these future…
The purpose of this prospective randomized controlled trial is to demonstrate that the EsophyX-TIF procedure will be more effective than PPI therapy as a short and long-term treatment of GERD.
Primary aim of the study is to compare the efficacy and safety of two flowrates of ITB while maintaining a constant daily dose.
The major research question is:Does a low-GI food product improve in healthy and obese men postprandial plasma concentrations of inflammatory markers as compared to a high-GI product?Major null hypothesis, H0:In healthy as well as obese men, a low-…
To evaluate the potential attenuating effects of a one-week supplementation with 2 x 250 mg caffeine per day on blood biomarkers of systemic inflammation in COPD patients.
To determine altered brain-activity during the performance of a sensitive perceptual-motor task following the administration of the antihistamine dexchlorpeniramine 4mg.
Primary:* To investigate the safety and tolerability of the co-administration of GSK598809 at175 mg and ethanol in healthy volunteers.* To examine the potential pharmacokinetic interactions between GSK598809administered at 175mg and ethanol in…
The objectives are:1. the effect of steady state concentrations of voriconazole and fluconazole on the steady-state pharmacokinetics of TMC125,2. the effect of steady-state concentrations of TMC125 on the steady-state pharmacokinetics of…
The objective is to study whether saturated fatty acids induce a different postprandial change in inflammatory markers than cis-polyunsaturated fatty acids.
The primary objective of this study is to evaluate the effect of colostrum supplementation on the immune response after intense strenuous exercise.The secondary objective is to study the effect of intense strenuous exercise - and its possible…
This study involves research and the objective of this study is to evaluate how much and how fast TMC278 is absorbed into the body after administration as these concept pediatric formulations compared to when administered as the 25 mg TMC278 tablet…
Primary objective: To determine the pharmacokinetic profile of lopinavir and ritonavir in two differ-ent co-formulations (Lopimune granules and Lopimune tablets) after single-dose in HIV-negative, healthy adult subjects, and to compare this to the…
The combination of simvastatin 10 mg/ezetimibe 10 mg has a beneficial effect on post prandial endothelial function in comparison to monotherapy with simvastatin 80 mg.
Primary objective:To assess whether a single day infusion of the GLP-1 RA exenatide, as compared to placebo, reverses GC-induced impairment of glucose metabolism and beta-cell function in healthy males
The aim of the study is to compare magnesiumhydroxide and polyethylene glycol/electrolytes with regard to the prevention of constipation and side-effects in palliative care cancer patients starting with opioids.
The main objective of this study is to determine whether and how the endocannabinoid system is involved in psychiatric disorders. We test this by assessing the acute effects of a cannabinoid agonist (THC) on brain systems that are known to be…
Primary Objective:* To investigate the effects of THC on fMRI activation patterns in healthy volunteersSecondary objective:* To assess the feasibility of pharmacokinetic/pharmacodynamic (PK/PD)-analyses for THC-induced fMRI-activation patterns* To…
The goal of this research is to see whether offering fluoride three times a day enhances the remineralisation of an early cariouslesion more than fluoride twice a day.
The main objective is to quantify the effect of high saltiness level versus low saltiness level in tomato soup on ad libitum intake.
The presently proposed study aims to investigate the effects of different dairy products, which are frequently used in the Netherlands and not yet analyzed, on Glycemic Index and Insulin Index in humans. This will be investigated by analyzing…