178 results
Cardiac surgery patients are often exposed to blood products perioperatively (18). Due to their underlying cardiac condition and ventricular dysfunction these patients are at an increased risk for TACO.(19) In a *proof of principle* approach we will…
The main objective of the study is to investigate if nicotinamide riboside supplementation can improve whole body and hepatic insulin sensitivity in overweight and obese men and women. As secondary objectives we want to investigate if nicotinamide…
There are three aims in this project: 1. To investigate how the functional interaction between the locus coeruleus and other brain areas, in particular the medial temporal lobe areas, during memory processes (encoding, consolidation and retrieval)…
Our primary objective is to test the hypothesis that there is an association between high CPS at baseline and a low relative effect from subacromial anaesthetics (as compared to subacromial placebo). The increased pain perceived by these patients…
The primary objective is to evaluate the effect of bright light on postprandial blood glucose metabolism in obese subjects with impaired fasting glucose, impaired glucose tolerance, decreased insulin sensitivity or increased Hb1Ac. Exploratory…
The aim of the study is to investigate effects of dapagliflozin on potential mechanisms explaining improved insulin sensitivity in skeletal muscles.
The main objective of this (pilot) study is to investigate the role of glutamate in cognitive functioning in adults with 22q11DS using a glutamatergic challenge (riluzole )and high-field MRS. We will relate glutamate concentrations in the striatum…
The main objective of this study is to investigate the underlying mechanisms responsible for insulin sensitivity after 4 days of sitting less compared to sitting and exercise in healthy obese women. Our secondary objective is to investigate the…
The primary objective is to determine whether a high-fat meal can induce a persistent pro-inflammatory monocyte phenotype, characterized by an increased cytokine production capacity upon ex vivo stimulation. Secondary objectives are metabolic and…
The primary objective is to evaluate the effect of UDCA and ezetimibe on cholesterol elimination assessed as total faecal sterol concentration. Secondary objective is to assess the effect of UDCA and ezetimibe on plasma lipid profile/composition.
The objective of this study is to evaluate the acute effects of sitting on cognitive measures in healthy elderly, and if these effects can be prevented by breaking-up sitting and/or a high mental activity state. In addition, this research explores…
The objective of the proposed experiments is to study the effect of lighting intensity and spectral composition (correlated colour temperature) on thermal comfort and thermo physiology. The obtained insights can be used to improve thermal comfort,…
(this text is taken from the protocol, see protocol for the detailed version)The main objective of the study is to gain insight in the underlying mechanism of tinnitus suppression. This objective will be achieved by comparing the suppressive effect…
Main aim; to show that NicVAX attenuates nicotine induced CNS effects on brain activation and cognitive performance relative to placebo. The secondary aim; to evaluate how these changes in CNS stimulation alter subjective measures and the addictive…
This project aims to study how changes in serotonin alter interpersonal functioning in adults with or without a first degree family member diagnosed with MDD. The primary goal is to investigate the effect of experimentally lowered brain serotonin…
1. to study the effect of spironolacton and triamterene on blood pressure in anuric hemodialysis patients.2. to study the effect of treatment on body weight, serum elektrolytes, 24-hours sodium excretion, plasma aldosterone and renin concentrations…
Primary Objective: 1. Will an exposure to oxygen with a PO2 = 190 kPa lead to changes primarily in DLno compared to DLco?Secondary Objectives: 1. After an exposure to oxygen with a PO2 = 190 kPa for one hour, are the changes primarily located in the…
To study the effect of pectin in 5 different physicochemical states on ad libitum energy intake and possible underlying mechanisms; i.e. gastrointestinal hormones, gastric emptying rate, feelings of satiety and the method of fiber supplementation.
The primary objective of the biomarker study is to validate existing biomarkers for protein from dairy, meat, and grain/ legumes, and to identify new potential biomarkers for these types of protein in urine. Secondary objectives are 1) to establish…