161 results
The objective of this crossover study and randomized controlled trial is to compare ΔP levels during INTELLiVENT®-ASV with conventional lung protective ventilation in patients with moderate or severe ARDS.
The effects of macronutrients on postprandial vascular function in overweight and slightly obese men
The primary objective of the proposed study is to evaluate the effect of the three macronutrients on postprandial vascular function, assessed by brachial artery flow-mediated vasodilation (FMD), in overweight and slightly obese male volunteers.…
The primary objective of the proposed study is to evaluate the effect of the high dose or L-arginine (3.0 gram) and a lower dose of L-arginine (1.5 gram) compared with a placebo supplement on postprandial vascular function, assessed by brachial…
To study the effect of TRH on opioid-induced respiratory depression in healthy volunteers.
The main objective of this study is to investigate the effects of wakame and spirulina consumption on intestinal cholesterol absorption. Secondary objects are to investigate the effects of wakame and spirulina consumption on cholesterol synthesis…
The primary objective of this intervention study is to evaluate in sedentary elderly men the effect of a 8-week aerobic-based exercise program on gray matter cerebral blood flow, as quantified by the non-invasive gold standard magnetic resonance…
The aim of the current study is to compare the acute effect of nitrate supplementation. Therefore, we will assess the impact of concentrated beetroot juice, high nitrate vegetables versus nitrate depleted beetroot juice (placebo) on exercise…
PrimaryTo assess the preventative effect of GLPG1205 on nociceptive and inflammation/sensitization induced pain in the UVB sunburn model using HPTol upon multiple dosing of GLPG1205 versus placebo.SecondaryTo further assess the preventative effect…
Evaluation of the effectiveness of a new system HD2/NBI2 to improve the detection of colorectal neoplastic lesions during colonoscopy in comparison to the former generation with currently highest share of the installed base (nonHD-nonNBI system i.e…
To assess the short-term (2 hours, and 2 days) effects of the egg protein hydrolysate on arterial stiffness in volunteers, aged 18-70 years with overweight and impaired glucose tolerance (defined as blood glucose >7.0 mmol/l and <11.0…
The major objective of the present study is to examine the effect of consuming vitamin E (804 mg) or lipoic acid (600 mg) for 4 weeks on fasting oxyphytosterol concentrations in subjects with impaired glucose tolerance or type 2 diabetes.
The objective of the study is to compare the effects of homogenized, unhomogenized and skimmed milk with butter on postprandial metabolism in healthy overweight men.
The major objective of the present study is to examine the effects of dietary plant sterols and stanols on fasting serum concentrations of oxyphytosterols. The minor objective is to investigate the effects of these products on postprandial serum…
The effect of NEAT or inactivity on insulin sensitivity and lipid metabolism is unclear. The objective of the present study is to evaluate the effect of 4 days of mainly sitting, or sitting and walking, or sitting, walking and biking on glucose and…
Effects of stearidonic acid on serum triacylglycerol concentrations in overweight and obese subjects
To study the effects of echium oil, rich in SDA on serum triacylglycerol concentrations in healthy overweight and slightly obese men and women. The minor objective is to study the effects of echium oil on the omega-3 index, which is negatively…
The FLAVO-studie is a scientific study aimed at investgating if (and how) certain pure flavonoids can beneficially influence vascular function.
1) To test and improve fall detection algorithms and predict the risk of falling during normal daily life. 2) To develop a feasible and effective training, that is suitable for diverse groups of elderly.
Primary Objective: •To investigate the effect of dietary sodium restriction on blood pressure and use of antihypertensive medication in renal transplant recipients.Secondary Objective(s): •To investigate the effect of dietary sodium restriction on…
Hypotheses: - Ileal delivery of casein and/or sucrose induces stronger effects on satiation compared to placebo- Ileal delivery of casein induces stronger effects on satiation than ileal fat delivery- Ileal delivery of sucrose induces stronger…
To study the protective effect of pre-treatment with metformin on flow mediated dilation after 20 minutes ischemia and 20 minutes reperfusion. If metformin treatment indeed limits endothelial IR-injury, a second study will be performed in the same…