399 results
To explore the effects of CST-101, CST-103, and CST-109 on CNS functions that are relevant to neurodegenerative disorders.
It is hypothesized that tianeptine will prevent alfentanil‐induced respiratory depression without affecting antinociception.
Cholesterol lowering by low fat diet and lovastatin will also reduce very long chain fatty acids in patients with X-ALD.
Oxytocin administration leads to stronger empathic reponses and faster emotional processing.
We hypothesize that bi-daily 5ml NaCl 7% nebulizations improve respiratory symptoms and quality of life in PCD patients compared to 5ml NaCl 0,9% nebulizations.
The administered protein mix is related to a faster postprandial amino acid bioavailability compared to a single protein as measured by the t½ of the iAUC.
MCT is more effective than ERP, both statistically significant and clinically relevant.
Amitriptyline ameliorates heartburn complaints in functional heartburn patients by modulating visceral perception.
A newly developed artificial saliva spray (Novospray) alleviates the feeling of a dry mouth in patients suffering from xerostomia better than placebo.
the correspondence between orosensation of sweetness and post-oral sensation of calories influences resting energy expenditure, cerebral blood flow and gastric emptying, and more specifically that the “not sweet enough” beverage, that contains more…
Deep brain stimulation (DBS) targeted at the ventral anterior limb of the internal capsule (vALIC) is an effective treatment for treatment-refractory obsessive-compulsive disorder (OCD). However, effective DBS for these patients requires relative…
1. Measure DNIC and offset analgesia in neuropathic pain patients; 2. Compare DNIC and offset analgesia in chronic pain patients with DNIC and offset analgesia in healthy volunteers; 3. Assess the effect of oral tapentadol on DNIC and offset…
Reduced dermal blood flow response to capsaicin application and saline iontophoresis after propranolol ocompared to placebo administration.
We hypothesize that UDCA on top of ezetimibe leads to an increased cholesterol excretion via the feces by stimulating ABCG5/8 and preventing absorption of cholesterol due to blocking NPC1L1 and therefore promoting elimination of cholesterol from the…
At equi-analgesia respiratory depression from oxycodone is manifold greater compared to Tapentadol
Inhalation of rhDNase before sleep increases the expiratory flow at 25% of the actual forced vital capacity (MEF25) compared to inhalation of rhDNase in the morning.
THC causes changes in resting state brain activity that can be visualized by fMRI
The endocannabinoid system is involved in cognitive functioning, and therefore, challenging this system with THC will influence cognitive processing in humans. Moreover, subjects with cognitive impairments (i.e. psychiatric patients) will react…
DBS in the nucleus accumbens can lead to long-term improvement of obsessive-compulsive symptoms and funtioning, without unacceptable side-effects.
This study is therefore aimed at quantifying the relative contribution of the two major receptor systhems involved in S(+) ketamine and methadone induced analgesia and side effects( respiratory depression,sedation,miosis).