64 results
1. DKD patients are salt-sensitive due to a decreased sodium buffering capacity (damaged ESL). As a consequence a high sodium diet will lead to water retention, resulting in increased ECF, body weight and blood pressure. 2. CKD patients are salt-…
Tumour cell disruption by radiation generates a surplus of neo-antigens that enhances the effect of immunotherapy in solid malignancies as well as malignant lymphomas. The hypothesis is that the combination of immune checkpoint inhibitors and…
Main hypothesis The BENEFIT intervention will significantly increase the number of CVD patients that can maintain the healthy lifestyle behavior most relevant to them for at least one year, compared to care-as-usual. Secondary hypothesis The BENEFIT…
Better glucose control during the closed loop system compared to standard open loop therapy
We hypothesize that the MMP could be cost-efficient for a part of the patients, but that for some patients a more simple prosthesis would be more cost-efficient. Therefore, we do not expect big differences in cost-effectiveness between the MMP and…
Golimumab 100 mg every 1,5 month has similar trough levels to golimumab 50 mg every month; golimumab 100 mg every 2 months has a similar AUC to golimumab 50 mg every month.
Hypothesis 1. The slopes of improvement are significantly stronger during ST than during control conditions (baseline, ST-preparation, communication training, follow-up). Hypothesis 2. The slopes of improvement in the sequence ST - Communication…
The flavonoid-drug interaction could potentially lead to higher nintedanib absorption by the gastro-intestinal tract. This would cause higher systemic bioavailability and lower local gastro-intestinal drug concentrations. Furthermore, inter-patient…
We hypothesize that the use of KomPas at the start and during the SET will be associated with increased functional walking distance, maximal walking distance and the quality of life of patients with Intermittent Claudication. Moreover, we…
Smart energy meter data used in a monitoring system to alert users when out-of-the-ordinary activity is detected, may improve health-related quality of life and perceived safety of community-dwelling older persons and their informal care providers.
We expect higher bioavailability of seaweed types containing more inorganic iodine, compared to seaweed types containing more or organic iodine.
• Overall, the patient-tailored PROfeel lifestyle advice will be more effective in reducing patients’ fatigue severity than the generic dietary advice. • Overall, the patient-tailored PROfeel lifestyle advice will have a more positive effect on…
Polystyrene sulfonate shows an in-vitro binding interaction with amitriptyline, causing 70-80% binding of amitriptyline to polystyrene sulfonate. The hypothesis is that polystyrene sulfonate binds to amitriptyline when taken simoultaneously in…
exercise improves social functioning, quality of life and decreases symptom severity
Cognitive remediation focused on executive functioning for patients with bipolar disorder improves executive functioning on (1) personal goals in daily life, and (2) general well-being. Exploratory hypotheses: - Cognitive remediation focused on…
The intended research aims to evaluate whether a better suppression of adrenal androgens, so a better hormonal setting, can be achieved by changing the time of the highest dose in the morning or in the evening.
The hypothesis of this study is that implementation of an evidence-based management algorithm to standardize care will improve the level of care, lower the complication rate and improve the quality of life for patients with chronic pancreatitis.
It is expected that patients prefer the AFO with the best efficacy, and that the preference is reliable at the moment of AFO fitting.
1. The addition of moderate positive end-expiratory pressure (PEEP, 7.5 cmH2O) to high inspiratory fractions of oxygen can either improve oxygenation or reduce respiratory rate, or both, in patients with severe Covid-19 pneumonia 2. The application…
We hypothesize that giving feedback to healthcare providers on the performance of their own hospital improves processes of care and leads to better outcomes.