285 results
1. To examine the effect of cold on post-prandial triglyceride metabolism using a standardized meal test during and after cold exposure 2. To examine the relationship between cold-induced brown adipose tissue activity and the changes in…
The main objective of the study is to determine the albuminuria lowering effect of the GLP1-RA exenetide, SGLT-2 inhibitor dapagliflozin and their combination in patients with type 2 diabetes and micro- or macroalbuminuria.Secondary objectives are…
The main objective of this study is to assess the efficacy of the closed loop system over an extended period. Secondary objectives are to assess the safety of the closed loop system; to determine the time that the control algorithm is active; to…
The main objective of the study is to investigate if nicotinamide riboside supplementation can improve whole body and hepatic insulin sensitivity in overweight and obese men and women. As secondary objectives we want to investigate if nicotinamide…
The primary objective is to evaluate the effect of bright light on postprandial blood glucose metabolism in obese subjects with impaired fasting glucose, impaired glucose tolerance, decreased insulin sensitivity or increased Hb1Ac. Exploratory…
Primary objective: To accurately assess the direct functional consequences of high versus low phenylalanine levels in adult patients with PKU, using eye-hand coordination testing in tasks of different cognitive complexity. Secondary objective: To…
The aim of the study is to investigate effects of dapagliflozin on potential mechanisms explaining improved insulin sensitivity in skeletal muscles.
The effects of macronutrients on postprandial vascular function in overweight and slightly obese men
The primary objective of the proposed study is to evaluate the effect of the three macronutrients on postprandial vascular function, assessed by brachial artery flow-mediated vasodilation (FMD), in overweight and slightly obese male volunteers.…
The primary objective of the proposed study is to evaluate the effect of the high dose or L-arginine (3.0 gram) and a lower dose of L-arginine (1.5 gram) compared with a placebo supplement on postprandial vascular function, assessed by brachial…
The purpose of this study is to investigate if there is a difference in the injection site pain experience after an injection under the skin (subcutaneous) with 2 different products, semaglutide and dulaglutide, in healthy volunteers. The 2 products…
Primary Objective * To evaluate the effect of a 6-week treatment with elafibranor versus placebo on hepatic lipid composition in subjects with a fatty liver.Secondary objectives * To evaluate the between treatment difference (elafibranor 120 mg/d vs…
The primary objective is to evaluate the effect of UDCA and ezetimibe on cholesterol elimination assessed as total faecal sterol concentration. Secondary objective is to assess the effect of UDCA and ezetimibe on plasma lipid profile/composition.
The primary objective of this intervention study is to evaluate in sedentary elderly men the effect of a 8-week aerobic-based exercise program on gray matter cerebral blood flow, as quantified by the non-invasive gold standard magnetic resonance…
The objective of the study is to gain insight in the role of endogenous GLP-1 on food-stimuli related CNS satiety and reward responses and the alterations between lean and obese-T2DM individuals. Also, to gain information about treatment with a GLP-…
To assess the effects of a 4-week high protein diet on body composition in obese children. Secondary outcomes are whole-body protein turnover, gluconeogenesis, energy expenditure, markers of the metabolic syndrome, appetite sensations,…
The major objective of the present study is to examine the effect of consuming vitamin E (804 mg) or lipoic acid (600 mg) for 4 weeks on fasting oxyphytosterol concentrations in subjects with impaired glucose tolerance or type 2 diabetes.
Primary objectiveTo measure the conversion rate of mono- and disaccharides into oligosaccharides and mannitol in the digestive tract by the action of food grade micro-organisms Secondary objectivesTo measure pH of gastric and duodenal fluids at…
The objective of the study is to compare the effects of homogenized, unhomogenized and skimmed milk with butter on postprandial metabolism in healthy overweight men.
The major objective of the present study is to examine the effects of dietary plant sterols and stanols on fasting serum concentrations of oxyphytosterols. The minor objective is to investigate the effects of these products on postprandial serum…
The effect of NEAT or inactivity on insulin sensitivity and lipid metabolism is unclear. The objective of the present study is to evaluate the effect of 4 days of mainly sitting, or sitting and walking, or sitting, walking and biking on glucose and…