161 results
The overall aim of this study is to achieve optimal QoL and ADL function in long term care falicity (LTCF) residents with moderate to (very) severe dementia and moderate to low QoL, and to achieve less care dependency, less pain, challenging…
To verify whether the emotional valence of the distracting task will affect the effects of the dual tasking procedure in a help seeking PTSS population.
To develop a second VRelax prototype for reducing impact of stress and test it in patients with depressive, bipolar, anxiety and psychotic disorders. User experiences and immediate effects on subjective stress and arousal will be investigated and…
The main objective of this (pilot) study is to investigate the role of glutamate in cognitive functioning in adults with 22q11DS using a glutamatergic challenge (riluzole )and high-field MRS. We will relate glutamate concentrations in the striatum…
Main objectives: The main aim of this study is twofold. We aim to (1) investigate whether rivastigmine can be used as a novel treatment to reduce ECT-induced interictal delirium and (2) to gain further insight into differences in determinants…
In short it is widely accepted that EMDR is effective in treating PTSD. EMDR however is not commonly used in treating PTSD patients when there is a comorbid BPD, even though it has been proven that PTSD can be successfully treated when people suffer…
Primary Objective: The primary objective is to show that L-theanine has beneficial anxiolytic in healthy individuals. With the current experiment setup that entails the following effects of L-theanine compared to placebo:• Reduced startle effect on…
The primary objective of the study is to determine whether TAK-653, in comparison to placebo, increases CNS excitability, assessed with TMS-evoked MEP in healthy subjects.Next to that, the study has the following goals: - To determine whether TAK-…
The primary aim of the current study is to examine the immediate effects of a brief compassion induction exercise on PD patients* affect regulation choice in response to imagery-based emotional salient experiences. A secondary aim is to assess to…
We will examine the cognitive performance of healthy young participants at different time points after a single administration of biperiden. The behavioural outcomes and electrophysiological correlates will be linked with the serum levels of…
The objective of this study is to evaluate the acute effects of sitting on cognitive measures in healthy elderly, and if these effects can be prevented by breaking-up sitting and/or a high mental activity state. In addition, this research explores…
The purpose of this study is to investigate how safe the new compound JNJ55375515 is when it is administered to healthy subjects. JNJ-55375515 has been administered to humans before and will be investigated at various dose levels.It will also be…
To investigate acute effects of a single 40 mg dose hydrocortisone, compared with placebo, on stress and various aspects of attention and other cognitive processing of emotionally relevant stimuli in healthy anxious young females. The main question…
This study aims to determine to which degree the offered help - according to our treatment program - for familymembers and partners of murdered persons helps to treat complicated grief and PTSD (Murphy, 2006, Shear et al 2006) and to gain insight…
This project aims to study how changes in serotonin alter interpersonal functioning in adults with or without a first degree family member diagnosed with MDD. The primary goal is to investigate the effect of experimentally lowered brain serotonin…
Our study aims at investigating whether male adults with ASD differ from healthy male adults in their neurophysiological responses to positive and negative empathy-evoking pictures when taking oxytocin intranasally once. To this end we will compare…
This study aims to investigate how serotonin influences social functioning in healthy adults with a first-degree family member diagnosed with MDD. The primary goal is to investigate the effect of an experimental increase in brain serotonin on…
The purpose of the study is to investigate how quickly and to what extent rivastigmine is absorbed and eliminated from the body when administered RTS for 7 days (this is called pharmacokinetics) as well as the safety of RTS.
Primary Objective:The primary objective in the current trial is to use graph theory to examine how the organization of the functional brain network may be altered by the administration of methylphenidate. The main question we intend to answer in…
In this functional Magnetic Resonance Imaging (fMRI) study, the primary objective is to examine the acute effects of intranasal OT administration on emotional- and reward-related brain processes in PTSD patients compared to traumatized healthy…