12 results
Primary Objective * To evaluate the effect of a 6-week treatment with elafibranor versus placebo on hepatic lipid composition in subjects with a fatty liver.Secondary objectives * To evaluate the between treatment difference (elafibranor 120 mg/d vs…
To assess the bioequivalence of two marketed formulations of ribavirin (ribavirin solution and capsules).
In this study, we aim to investigate the difference in the anabolic postprandial bile acid response between an enteral and parenteral mixed meal test (MMT) in healthy lean men. This study is important because it may give a better understanding of…
The primary objective of this study is to investigate to what extent hepatic fat oxidation can be stimulated by lowering hepatic glycogen content during a prolonged overnight fast. The secondary objective is to investigate whether reductions in…
The purpose of the study is to investigate how quickly and to what extent EYP001a is absorbed into, distributed in and eliminated from the body (this is called pharmacokinetics) when EYP001a is administered with and without food. It will also be…
To investigate the potential beneficial effect of increasing protein in the diet in order to decrease hepatic lipid accumulation on a high-fat diet.
Primairy objective:To determine the effect of a 4-week high SFA diet compared to a 4-week high fructose diet on hepatic insulin sensitivity (determined by insulin-stimulated suppression of endogenous glucose production).Secondary objectives: - To…
Primary Objective: To investigate whether a two-week low compared to high GI/SFA diet reduces liver fat content. Exploratory Objectives: To investigate whether a two-week low compared to high GI/SFA diet:* reduces DNL* lowers the 24-hour glycemic…
The purpose of this study is compare a tablet formulation of PXL770 to the capsule formulation of PXL770. It will be investigated how quickly and to what extent PXL770 in each formulation is absorbed and eliminated from the body. To limit the…
The primary objective of this study is to examine to what extent hepatic glycogen is decreased after a prolonged overnight fast in healthy volunteers with a normal weight and low liver fat percentage.
To quantify fructose that escapes the portal circulation and appears in the systemic circulation, by measuring serum fructose using ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) within 150 minutes following intake of…
Metabolic effects of ketohexokinase inhibition in individuals with non-alcoholic fatty liver disease
Primary objective: determining the effect of the ketohexokinase inhibitor, PF-06835919, on hepatic insulin sensitivity in individuals with non-alcoholic fatty liver disease.Secondary objective: determining the effect of the ketohexokinase inhibitor…