21 results
1. To examine the effect of cold on post-prandial triglyceride metabolism using a standardized meal test during and after cold exposure 2. To examine the relationship between cold-induced brown adipose tissue activity and the changes in…
The primary objective is to explore the efficacy of nintedanib (as measured by progression free survival) as second line therapy for patients with either differentiated or medullary thyroid cancer progressing after first line therapy.
The effects of intravenous TRH administration on brown adipose tissue activity in healthy, lean men.
To investigate whether BAT tissue can be activated by intravenous administration of TRH. Secondary objectives are to determine whether intravenous TRH increases the degree of cardiovascular sympathetic stimulation and the response of skin…
To evaluate the effects of intranasal oxytocin versus placebo on social behaviour and also on eating behaviour in children with PWS.
We will determine in a prospective cohortl study, differences between frequent screen users and infrequent screen users in sleep onset time, wake-up time, mid-sleep time, sleep duration, body mass index and melatonin onset. In the randomized cross-…
The purpose of this study is to demonstrate the effectiveness of the multiple dose dispenser in comparison to the syringe as measured by a testsoterone pharmacokinetic profile
The aim of this study is to investigate whether a physiologically low hydrocortisone (HC) dose is better for cognition as compared to a high hydrocortisone dose. In addition, quality of life, metabolic profile and somatosensation will be described…
We will evaluate the acute effects of GH on, and its relation with, cognition in healthy subjects. The present proposal focuses on the following questions:1. Does an acute rise of plasma GH levels have a (beneficial) effect on cognitive performance…
To investigate if there is a correlation between the peak GH concentrations after ingestion of gelatin protein and the peak GH concentrations after the two standard tests (GHST) in order to discriminate between GHD and non-GHD. To investigate the…
Primary objective: To explore whether prolonged moderate alcohol consumption affects in vivo cytokine response after a low dose of LPS in young, normal-weight men.Secondary objectives: To explore whether prolonged moderate alcohol consumption-…
Primary objectives: Stress response: To determine whether acute alcohol consumption shortly after a psychological/mental stressor attenuates the stress response recovery.Cholinergic status: To determine whether prolonged moderate alcohol consumption…
To study in a large randomised double-blind trial, if the administration of levothyroxine at bedtime significantly changes TSH and thyroid hormone levels compared to morning administration. Furthermore we want to evaluate the change of quality of…
To examine the effects of odors and / or visual stimuli of food in subjects after 56h of starvation on:-Endocrine parameters-Metabolic parameters-Anthropometric parameters-Autonomic nervous system parameters-Hypothalamic function
Primary objective:- To define the overall effect of oral Levothyroxine on coagulation parameters.Secondary objectives:- To define the specific effect of Levothyroxine on each tested coagulation parameters.- To define the specific effect of…
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Do high plasma free fatty acids lower central serotonergic responsivity?
to investigate whether showering shortly after Androgel application adversly affects plasma testosterone levels.
The primary objective of this prospective international multicenter diagnostic study is the comparison of the diagnostic accuracy between copeptin measurement after arginine-stimulation (CAS) and the current best diagnostic test copeptin measurement…
To evaluate the effects of N-acetylcysteine (NAC; Fluimucil® in Dutch) on skin picking behaviour in children and young adults with PWS.
This study aims to re-examine the bioequivalence of prednisolone and dexamethasone at two different doses by assessing tissue specific glucocorticoids effects, including the immune system, brain functioning, hormonal axes, and renal parameters.