2922 results
1. To examine the effect of cold on post-prandial triglyceride metabolism using a standardized meal test during and after cold exposure 2. To examine the relationship between cold-induced brown adipose tissue activity and the changes in…
The specific mechanism of inhibition differs between SST variants, it remains the question why. Our envisaged study focuses on this question. We expect that the difference is caused by the amount of perceptual overlap between the go stimulus and the…
The main objective of this study is to determine whether creatine monohydrate supplementation enhances diet-induced thermogenesis and brown adipose tissue activity in young, healthy adults, as quantified through PET-MR, following an acute cold…
The main objective of the study is to determine the albuminuria lowering effect of the GLP1-RA exenetide, SGLT-2 inhibitor dapagliflozin and their combination in patients with type 2 diabetes and micro- or macroalbuminuria.Secondary objectives are…
Main objectivePart A: To evaluate the safety and efficacy of treatment with VX-371, administered with and without 4.2% hypertonic saline (HS) in subjects with primary ciliary dyskinesia (PCD) who are *12 years of age.Part B: To evaluate the safety…
The primary objective is to assess the relative bioavailability of iron from insect added to either a high- or low-phytate meal in humans and its potential to provide bioavailable iron. The secondary objective is to determine whether addition of…
The main objective of the present study is to investigate whether it is possible to use the VOC pattern in exhaled air as a parameter of metabolism of lipids.Primary Objective: To investigate the difference in postprandial change in volatile organic…
The objective of this crossover study and randomized controlled trial is to compare ΔP levels during INTELLiVENT®-ASV with conventional lung protective ventilation in patients with moderate or severe ARDS.
The main objective of this study is to assess the efficacy of the closed loop system over an extended period. Secondary objectives are to assess the safety of the closed loop system; to determine the time that the control algorithm is active; to…
The primary objective is to investigate the effects of dopamine receptor stimulation on neural and behavioural measures of perception and consciousness. The secondary objective is to establish the relation between the effects of dopamine stimulation…
The primary objective of this study is to investigate if the intra-patient variability in tacrolimus pharmacokinetics is reduced by switching patients from maintenance tacrolimus treatment with tacrolimus-Prograft to either Advagraf or to Envarsus.…
The current study will examine the safety and pharmacokinetic profile of JWH-018.
The primary objective of this study is to compare pain suppression in two groups of subjects with chronic unilateral limb pain as a result of FBSS. Low Frequency spinal cord stimulation settings and High Frequency spinal cord stimulation settings…
Cardiac surgery patients are often exposed to blood products perioperatively (18). Due to their underlying cardiac condition and ventricular dysfunction these patients are at an increased risk for TACO.(19) In a *proof of principle* approach we will…
The main objective of the study is to investigate if nicotinamide riboside supplementation can improve whole body and hepatic insulin sensitivity in overweight and obese men and women. As secondary objectives we want to investigate if nicotinamide…
1) Objective: To compare the overall survival (OS) of previously-treated subjects with NSCLC in the strongly positive PD-L1 stratum treated with MK-3475 compared to docetaxel.2) Objective: To compare progression-free survival (PFS) per RECIST 1.1 by…
Primary objective:To assess pharmacokinetic similarity of EBR/GZR as a crushed (test) Zepatier tablet compared to a whole (reference) tablet.Secondary objective:To assess Cmax similarity of EBR/GZR as a crushed (test) Zepatier tablet compared to a…
Primary objective:- To evaluate the effect of JZP-110 on driving performanceSecondary objectives:- To evaluate the safety and tolerability of JZP-110- To explore SAFTE (Sleep, Activity, Fatigue, and Task Effectiveness) modeling using driving,…
The overall aim of this study is to achieve optimal QoL and ADL function in long term care falicity (LTCF) residents with moderate to (very) severe dementia and moderate to low QoL, and to achieve less care dependency, less pain, challenging…
A better understanding on the individual response to different albuminuria lowering drugs and a better understanding why these drugs, of which some are developed for another indication, may help to tailor optimal therapy. Therefore in this study…