14488 results
A clinical pilot-study were we will look if one time shock wave therapy on the distal radius leads to an increased bone mass. At the same time we would like to study if shock wave therapy of the distal radius could result in complications and we…
The objective of the study is to diminish the amount of chemotherapy and/ or radiotherapy for children with Hodgkin lymphoma who are likely to receive too much treatment with current treatment protocols.
Primary objectiveTo compare the efficacy of subpurpuric pulsed dye laser treatment with different intervals between treatment sessions.Secondary objectiveTo evaluate the safety and the long-term effects of subpurpuric pulsed dye laser treatment.
The objective of the current study is to compare three different strategies of pain management in patients presenting to an emergency department and to a general practice with acute musculoskeletal syndromes (defined as musculoskeletal complaints…
Primary objective *To evaluate the efficacy of 2 dose combinations of solifenacin and mirabegron compared to solifenacin and mirabegron monotherapySecondary objectives*To evaluate the efficacy of 2 dose combinations of solifenacin and mirabegron…
Primary Study Objective: To evaluate the effect of telotristat etiprate versus placebo over the double-blind portion of the study on the incidence of treatment-emergent adverse events (TEAEs)
Evaluation of the histologically proven adenoma or carcinoma detection rate in patients undergoing a full colonoscopy with and without mucosal contrast enhancement, obtained with 200 mg of Methylene Blue MMX® tablets. The lack of mucosal contrast,…
The goal of this study is to determine whether radiosensitization with carboplatin or the addition of Isotretinoin to maintenance therapy improves cure rates for children with other than average risk medulloblastoma/PNET.
PRIMARY OBJECTIVESthe assessment if survival in grade III glioma without combined 1p/19q loss is improved by - daily temozolomide chemotherapy during radiotherapy - the administration of temozolomide after the end of radiotherapy SECONDARY…
The primary objective of the study is to demonstrate the reduction of low-density lipoprotein cholesterol (LDL-C) by a regimen including an alirocumab starting dose of 150 mg Q4W as add-on to non-statin lipid modifying background therapy or as…
To compare the EEG pattern after administration of cyclopentolate with the EEG pattern after placebo eye-drops.Primary outcomeEEG pattern changes after administration of two drops of cyclopentolate1% compared with placebo.Secondary outcomes- Pattern…
The objective of this study is to investigate the effectivity on reducing or cessation of cocaine use of 1) working memory training, 2) N-acetylcysteine, 3) the combination of working memory training and N-acetylcysteine. Clinical measures (cocaine…
The objective of the present study is to investigate whether home-based exercise training with telemonitoring guidance results in improved long-term physical fitness and higher activity levels than regular centre-based exercise training in patients…
The main objectives are to evaluate the efficacy (as measured byprogression free survival at 6 months) of pertuzumab combined withtrastuzumab (PH) or PH plus metronomic chemotherapy (PHM) in anelderly metastatic breast cancer population, and to…
Determine efficiency and safety of two different doses of pregabalin as compared to placebo.
The primary objective of this study is to determine the influence of intra-operative use of remifentanil versus fentanyl on the percentage of patients with chronic thoracic pain one year after cardiac surgery. The secondary objectives are to…
The primary objective of this randomized trial is to assess the beneficial effects of early administration of 5 mg Metoprolol intravenously before reperfusion on infarct size in patients with ST elevation myocardial infarction who are planned to…
MK-1439 is a promising NNRTI to be used in combination with other antiretrovirals (ARTs) for the treatment of HIV infection. It is a potent inhibitor of HIV-1 replication in vitro and is active against both wild type virus and most common NNRTI…
To assess if a continued rehabilitation program in the first six weeks post-surgery for patients following a first time is morecost-effective as compared to no further treatment after discharge from the hospital an economic evaluation alongside…
The objective of the study is to determine whether exposure to the SpectraMax light therapy device, emitting light in a combined spectra of blue/green light (460 * 570 nm) with an intensity of approximately 1300 Lux, will be more effective in…