425 results
Primary Objectives-To evaluate if mitochondrial dysfunction can be induced in healthy, middle aged subjects, through the use of simvastatin, and whether it can be reversed by oral ubiquinol supplementation. -To validate the techniques NIRS, PpIX-…
Primary ObjectiveTo investigate whether ultrasound guided tumor resection succeeds gross total resection significantly more frequently, when compared with the conventional non-ultrasound guided tumor resection.Secondary Objective(s)To investigate…
Evaluation of the histologically proven adenoma or carcinoma detection rate in patients undergoing a full colonoscopy with and without mucosal contrast enhancement, obtained with 200 mg of Methylene Blue MMX® tablets. The lack of mucosal contrast,…
Studying the effect of two intervention programs (1. Motor Imagery Training, 2. Cognitive Orientation to Daily Occupational Performance (CO-OP)) on the motor abilities, motor imagery and motor planning capacities in children with Developmental…
The primary objective is to compare metformin versus no intervention for incidence of GDM in women with a high risk for GDM. The main secondary objective is pregnancy outcome with Metformin, neonatal outcomes and neonatal complications.
EFFICACY OBJECTIVESThe primary efficacy objective of this study is to evaluate the efficacy of intravitreal injections of 10 mg lampalizumab administered Q4W or Q6W in CFI profile biomarker positive and CFI profile biomarker-negative patients…
The aim of this study is to compare the additional diagnostic yield (adenoma detection rate) of G-EYE colonoscopy with that of standard high definition colonoscopy.
This study aims to provide a more rational evidence base for appropriate management for metastatic melanoma in the groin LNs, through assessing the effect of the addition of ipsilateral pelvic lymphadenectomy on patient disease-free survival (DFS),…
The study is intended to (1) confirm the reduced x-ray shadow of the MicroTEE (S8-3t) probe, and to asses whether this results in a more delayed first pull back or a reduction in the number of pull backs or not; and (2) to evaluate the feasibility…
RESEARCH QUESTION(S): Can in vivo reflectance confocal microscopy (RCM) correctly identify the subtype of basal cellcarcinoma (BCC)?Primary Objective: To study whether in vivo reflectance confocal microscopy (RCM) can correctly identify the subtype…
Closed reduction of a distal radius fracture is a treatment frequently performed by an emergency physician. The procedure is performed blind, meaning no visualization of the bony parts is possible during reduction. Whenever assumed that the position…
Mobile phones in cryptogenic strOke patients Bringing sIngle Lead ECGs to detect Atrial Fibrillation
The main objective of this study is to compare the incidence of detected AF in cryptogenic stroke patients by the AliveCor with the incidence of detected AF by a 7-Day Holter ECG.
The main purpose of this study is to assess whether MRI-targeted biopsy can detect a similar amount of cancer as 10-12-core TRUS biopsy.
Primary objectiveTo evaluate the efficacy of low dose intravenously lidocaine in comparison with placebo in terms of pain relief after the first oxaliplatin administration measured by a numeric rating scale (NRS 0-10).Secondary objectives1.…
Adding PCT measurements to standard diagnostics to support decision making regarding initiation of antibiotics. To evaluate an advantage of PCT guided prescription of antibiotic treatment over established treatment practice with respect to 90-day…
Primary Objective: To demonstrate the safety and efficacy of an OCT guided strategy for stent implantation.Trial Hypothesis: OCT-guided stent placement with application of a novel algorithm is non-inferior to IVUS-guided stent placement and superior…
Our primary objective is to investigate the effects of endotoxin-induced systemic inflammation and subsequent development of endotoxin tolerance on the inflammatory response following Fluenz® administration in vivo. To evaluate whether these effects…
The study will compare the change in cutaneous cellular oxygen availability, measured as mitochondrial PO2 (mitoPO2) between a fluid challenge and a blood transfusion in chronic anemia patients.
4.1 The main questionWhat is the effect of temporarily stopping PPI use on the stomach wall uptake of Tc99m Sestamibi with a myocardial perfusion?4.2 Sub-questions:- What is the relative maagwanduptake a myocardial perfusion Tc99m Sestamibi with…
Primary objective: Minimizing and optimizing radiation dose while maintaining sufficient image quality in patients with THA. Secondary objective: Reducing metal artefacts and thus in addition further improving the overall image quality using O-MAR.