3 results
* To evaluate the safety and tolerability of adding multiple oral doses of HTL0018318 in elderly volunteers taking donepezil at steady state.* To compare the pharmacokinetic profiles of HTL0018318 and donepezil when given alone and in combination at…
The primary objective is to determine an effect of sleep deprivation on CSF Aβ42 levels in humans.Secondary objectives: -Effect of unrestricted sleep on CSF Aβ42 levels.-Effects of unrestricted sleep and sleep deprivation on other known AD…
To determine the efficacy of the combinations of retifanlimab + INCAGN02385 (TG2) and retifanlimab + INCAGN02385 + INCAGN02390 (TG3) compared with retifanlimab alone (TG1) in the overall study population.