45 results
It is hypothesized that bCBT for severe fatigue will lead to clinical improvements in fatigue levels compared to usual care.
The study objective of the trial was to test the hypothesis that treatment with mepolizumab only affects inflammatory eosinophils whereas treatment with benralizumab affects both inflammatory and resident eosinophils.
- Six weeks of ESM combined with personalized feedback sessions, compared with treatment as usual (TAU), leads to a stronger reduction in fatigue symptoms (primary outcome clinical effectiveness). - This intervention also leads to improvements in…
We hypothesise that endoscopic sphincterotomy before biliary fully covered self-expandable metal stent (FCSEMS) placement may reduce the occurrence of post-ERCP pancreatitis by widening the orifice of the major duodenal papilla and reducing…
The ProIntens study aims to evaluate the impact of an intensive dietetic care pathway on dietary protein intake and physical functioning in older adults during hospitalisation and after discharge. Process and economic evaluations will be performed
We hypothesize that pupils who receive HL will have lower levels of depressive symptoms and higher levels of well-being than pupils who do not receive HL at 6-months follow-up.
We expect that all three treatments are effective. However, the posterior tension night splint might be earlier effective compared to the other treatments.
HFpEF patients have impaired peripheral microvascular function compared to controls without HFpEF, with correction for important confounders of microvascular function.
We hypothesized that intensive GDM treatment according to the new (2013) GDM criteria would result in a reduction in infants with birth weight >90th centile (large for gestational age, LGA), in comparison to treatment according to the old…
The main objective is to study the effect of a nutritional intervention on white matter integrity at the corrected age of three months in infants born at a gestational age <30+0 weeks. Secondary objectives of the study are to determine the…
We hypothesize that improving sleep will improve glycaemic control in people with T2DM and insomnia.
Renal artery denervation (RDN) on top of pulmonary vein isolation (PVI) will improve the success of ablative therapy for patients who have paroxysmal and/or persistent atrial fibrillation, with out of range hypertension (systolic >140 mmHg or…
rTMS in combination with CBT is a more (cost)effective treatment option for patients with non-psychotic depression with a moderate level of treatment resistance compared to treatment as usual (switching to a tricyclic antidepressant (TCA) or…
The main hypothesis is that specific mechanisms of action and level of immunosuppressive medication is the most important determinant of SARS-CoV-2 immunity after vaccination or infection in ISP patients.
Patients in the intervention group will be stimulated to increase their level of PA and protein intake after hospital discharge by using multiple behavioural change techniques. Higher levels of PA and achieving protein requirements are expected to…
Active surveillance is non-inferior to surgery in patients with oesophageal cancer showing complete clinical response after neoadjuvant chemoradiotherapy.
To establish the best treatment of patients with symptomatic haemorrhoids grade III: haemorrhoidectomy versus rubber band ligation (RBL). Patient bound effectiveness, clinical effectiveness and cost-utility of both treatments is compared;…
Point of care testing with Fcal POCT will reduce substantial the referral rate of children with chronic GI symptoms to the paediatrician.
We hypothesise that patients in the intervention group will show a reduction in sedentary time of at least 60 minutes per day after the cardiac rehabilitation program, compared to a reduction of maximally 30 minutes per day in the control group.
Effective postoperative pain control is an essential and humanitarian need of every surgical procedure. Inadequate pain control may result in increased mortality, delayed recovery and increased hospital costs (1). The optimal perioperative analgesic…