1539 results
The primary objective for part I of the study is the investigation of the pharmacokinetics. Although there is substantial clinical experience with all components of HTX-011, the formulation itself and the route of administration is new, which…
Primary Objectives-To evaluate if mitochondrial dysfunction can be induced in healthy, middle aged subjects, through the use of simvastatin, and whether it can be reversed by oral ubiquinol supplementation. -To validate the techniques NIRS, PpIX-…
Primary Objectives:• Part 1: To evaluate the safety and tolerability of ruxolitinib in combination with pemetrexed/cisplatin and select a dose for further evaluation• Part 2: To evaluate and compare the overall survival of subjects with nonsquamous…
Primary Objective: We aim to investigate the possibility of erasing multimodal memories by applying repetitive TMS to a somatosensory region that represents part of the memory trace. Specifically, we expect that application of the stimulation…
The REDUQ II study will be conducted to help us to complete data on the secondary endpoints of the REDUQ study (P09-22) and arrange and examine relationships occurring between and among intervention elements of the REDUQ study, behavioural and…
The objective of the current study is to compare three different strategies of pain management in patients presenting to an emergency department and to a general practice with acute musculoskeletal syndromes (defined as musculoskeletal complaints…
The primary objective of the study is to demonstrate the reduction of low-density lipoprotein cholesterol (LDL-C) by a regimen including an alirocumab starting dose of 150 mg Q4W as add-on to non-statin lipid modifying background therapy or as…
To compare the EEG pattern after administration of cyclopentolate with the EEG pattern after placebo eye-drops.Primary outcomeEEG pattern changes after administration of two drops of cyclopentolate1% compared with placebo.Secondary outcomes- Pattern…
The objective of this study is to investigate the effectivity on reducing or cessation of cocaine use of 1) working memory training, 2) N-acetylcysteine, 3) the combination of working memory training and N-acetylcysteine. Clinical measures (cocaine…
The primary objective of this study is to determine the influence of intra-operative use of remifentanil versus fentanyl on the percentage of patients with chronic thoracic pain one year after cardiac surgery. The secondary objectives are to…
The objective of the study is to determine whether exposure to the SpectraMax light therapy device, emitting light in a combined spectra of blue/green light (460 * 570 nm) with an intensity of approximately 1300 Lux, will be more effective in…
Primary:The primary objective of Study 218MS305 is to determine whether prolonged-release fampridine (10 mg BID) has a clinically meaningful effect on patient-reported walking ability over a 24-week study period.Secondary:The secondary objectives…
Primary Objective: 1. To assess the difference in treatment effect (change in functional disability between pre-treatment and 12 months of follow-up post-treatment) between the new primary care intervention *Back on Track* and primary care as usual…
The study will be performed in 2 parts, Parts A and B. The purpose of Part A of the study is to investigate the safety of VX 150 and to what extent a single dose of VX 150 is tolerated. It will also be investigated how quickly and to what extent a…
To determine whether computerized training procedures can lead to a decrease of aggression-related attention andinterpretation, and whether this reduces aggressive behaviors.
Determine if the use of Glymur oral rinse for 14 days has an effect on the composition of the oral microbiota. In addition, the effect on total microbial proteolytic activity and oral malodor will be determined.
The primary objective is to determine the effects of dietary nitrate (beet root juice) on the microcirculatory profile in healthy adults. The secondary objectives are 1) to determine the effects of dietary nitrate on macrocirculatory parameters, 2)…
In the current study we will investigate the effect of non-pharmacological treatment on postoperative acute pain and PONV in patients undergoing a laparoscopic cholecystectomy. Patients will receive on the recovery an ice-lolly, chewing gum or no…
Primary objective: To assess the impact of a low glycaemic load (GL) diet as compared to a *Western* diet on metabolic flexibility (the change in RQ) upon a hyperinsulinemic euglycemic clamp. Secondary objectives: 1) To assess the impact of low GL…
Study 1 is aimed to describe normative trajectories of parenting efficacy from pregnancy to early parenthood. Study 2 is focused on the question whether mental representations of attachment are protective in the context of parenting stress and its…